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Abstract Purpose of Review The glucagon-like peptide 1 (GLP-1) receptor agonists (RAs) liraglutide and semaglutide, and the dual GLP-1/glucose-dependent insulinotropic polypeptide (GIP) RA tirzepatide are approved for the treatment of overweight and obesity

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For example, after 2 years of treatment with liraglutide 2.4/3.0 mg in patients with obesity, 52% and 26% maintained at least 5% and at least 10% weight loss, respectively, compared with 29% and 16% of patients receiving orlistat [47] (Table 1)

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